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Cessation of GLP-1 RA therapy is associated with weight regain, and although current evidence does not provide conclusive findings regarding sarcopenia, the tendency to regain more fat than muscle mass, together with a potential decline in muscle quality, may pose a risk [98]

Based on previous research, TAM-targeted strategies can be divided into four types: (1) suppressing macrophage recruitment

Knowledge about intestinal peptides was not only aided by the arrival of new extraction and purification methods but also by advances in microscopy

Subsequently, through reverse-phase purification technology, GLP-1 analogues that meet the purity requirements can be obtained

Apart from this, metformin can cause changes in the microbial composition of the intestinal tract (Vallianou et al., 2019), increased lactic acid production (Misbin et al., 1998), and increased concentrations of glucagon-like peptide-1 (GLP-1) and bile acids (Mannucci et al., 2004